The Interrogatory of the year 1755 is the document which had to carry out the city of Lorca to elaborate the "Catastro de la Ensenada". lt has been possible to know, through it, the productive structure of a rural, gremial and conservative country where the political powder was kept by the oligarchy. In this paper we have studied the division and use of the land, its production, yields, prices and taxes as well as the manufacturing, comercial and industrial activities. Also, (...) this paper allow us tho know the distribution of the employed people and their rentallevel, and also show the way in which the burocracy gives to this rural country sorne urban character. We have tried to carry out an approach to a pre-industrial society of the "Old Regimen" which has an important density of population and where the guilds gave to this society gremial character. (shrink)

Business Ethics: A European Review, EarlyView.

Various research groups with ongoing projects in the areas of personal data protection, reuse of public sector information and open data organised a seminar on October 29, 2020, on reuse and big data in the field of health in which researchers, managers and policymakers from different disciplines participated. Starting from the premise of the special importance that access to health data has as a resource for research, management and development of health products, treatments and interventions and, at the same time, (...) its consideration as a special category of data that is particularly sensitive, private and protected, this document seeks to systematise the main conclusions reached. (shrink)

RESUMEN El presente artículo trata de mostrar las varias y diversas interpretaciones y posiciones existentes con respecto a la filosofía de Feuerbach, lo cual revela la influencia e importancia de su pensamiento. Así mismo, más allá de los diversos intentos por periodizar la obra de Feuerbach, el artículo trata de mostrar en qué medida es posible afirmar la existencia de un principio interno explicativo de su filosofía, el cual puede encontrarse en el concepto mismo de crítica, referido tanto a su (...) método como a su actitud filosófica. Esta crítica tiene, en cualquier caso, un sentido positivo y trata de reafirmar una concepción plena del ser humano. ABSTRACT This paper tries to show the various and diverse interpretations and positions regarding Feuerbach's philosophy, what reveals the influence and importance of his thought. Likewise, beyond the various efforts to periodize Feuerbach's works, it tries to show how it is possible to affirm the existence of an internal explanatory principle to his philosophy, which can be found in the very concept of critique, referring both to his philosophical method and attitude. This critique has, in any case, a positive sense and tries to reassert a full conception of human beings. (shrink)

Background: This research explores how public awareness and attitudes toward donation and transplantation policies may contribute to Spain's success in cadaveric organ donation. Materials and Methods: A representative sample of 813 people residing in Andalusia (Southern Spain) were surveyed by telephone or via Internet between October and December 2018. Results: Most participants trust Spain's donation and transplantation system (93%) and wish to donate their organs after death (76%). Among donors, a majority have expressed their consent (59%), and few nondonors have (...) expressed their refusal (14%). Only a minority are aware of the presumed consent system in force (28%) and feel sufficiently informed regarding the requirements needed to be an organ donor (16%). Participants mainly consider that relatives should represent the deceased's preferences and be consulted when the deceased's wishes are unknown, as is the case in Spain. Conclusion: Public trust in the transplant system may contribute to Spain's high performance in organ donation. High levels of societal support toward organ donation and transplantation do not correspond with similar levels of public awareness of donation and transplantation policies in Spain. (shrink)

The activity of Wnt and Notch signalling is central to many cell fate decisions during development and to the maintenance and differentiation of stem cell populations in homeostasis. While classical views refer to these pathways as independent signal transduction devices that co‐operate in different systems, recent work has revealed intricate connections between their components. These observations suggest that rather than operating as two separate pathways, elements of Wnt and Notch signalling configure an integrated molecular device whose main function is to (...) regulate transitions between cell states in development and homeostasis. Here, we propose a general framework for the structure and function of the interactions between these signalling systems that is focused on the notion of ‘transition states’, i.e. intermediates that arise during cell fate decision processes. These intermediates act as checkpoints in cell fate decision processes and are characterised by the mixed molecular identities of the states involved in these processes.Editor's suggested further reading in BioEssays: Notch: Implications of endogenous inhibitors for therapy Abstract. (shrink)

This writing is an homage to Professor Jorge Ayala Martínez because of his many merits in the course of his life as a teacher in different centers, especially in the University of Zaragoza, and as an investigator. His speciality is Philosophy, above all the Spanish, Aragonese and Medieval Philosophy, and other matters. On the other hand his work as a secretary and editor of this magazine Medieval Philosophy Society has been very praiseworthy and effective.

Humboldt Revisited offers a fresh perspective on the contemporary discourse surrounding reform of European universities. Arguing that contemporary reform derives its basis from pre-constructed truths about the so-called 'Humboldt-university,' this monograph traces the historical descent of these truths to the American reception of Humboldt's ideas from the mid-19th century up until the 1960s. Drawing from a rich selection of historical sources, this volume offers an alternative to conventional explanations of the forces behind the ongoing reform of European universities. It also (...) challenges the conventional historical narrative on the Humboldt University, providing new insight into the American reception of the German ideas. (shrink)

ABSTRACTThe aim of this paper is to bring a phenomenological perspective to bear on a specific problem: how to understand the diminished sense of reality that is often reported by persons who have suffered severe and prolonged interpersonal trauma. For this purpose I turn to resources from two traditions. First, I present a phenomenological account of the intersubjective constitution of objective experience, which is then complemented by a developmental account of how the very small child comes to inhabit a world (...) of shared mind-independent things. On this basis, I aim to show how the sense of reality, as the clear and dependable sense of the difference in experience between inner life and external reality, is an interpersonal developmental achievement that goes hand in hand with the development of the sense of self. I will in particular draw on Husserlian phenomenology and Winnicott’s psychoanalytic perspective on developmental psychology. (shrink)

In ‘Currying omnipotence: A reply to Beall and Cotnoir’, Andrew Tedder and Guillermo Badia argue that Jc Beall and A. J. Cotnoir’s gappy solution to the traditional paradox of unrestricted omnipotence does not extend to a Curry-like version of the paradox. In this paper, we show that it does extend to it.

Certain health care services and goods, although legal and often generally accepted in a society, are by some considered morally problematic. Debates on conscientious objection in health care try to resolve whether and when physicians, nurses and pharmacists should be allowed to refuse to provide medical services and goods because of their ethical or religious beliefs. These debates have most often focused on issues such as how to balance the interests of patients and health care professionals, and the compatibility of (...) conscientious objection with professional obligations, but it is also possible to think about conscientious objection in terms of how to respond to moral disagreement and the requirements of liberal neutrality. (shrink)

Research on ethical, legal and social aspects of life sciences and new technologies has mainly been focused on impacts and consequences, while the emerging framework of Responsible Research and Innovation focuses rather on increased involvement and reflexivity in research processes to foster science and technology that better answers the needs of society. I argue that philosophy of science should be a central feature of RRI and demonstrate how the philosophy of science can contribute in this sense. I show how investigating (...) basic assumptions in research, here exemplified by reductive assumptions in causal modeling, can have important ethical and societal implications. (shrink)

Lynch et al. (Biol Philos 34:62, 2019) employ stability, specificity, and proportionality as criteria for evaluating microbiome causal explanations. Although these causal characteristics signify relevant differences between causal roles, I suggest that they should not be used as general criteria for strong or good causal explanations.

The method in human genetics of ascribing causal responsibility to genotype by the use of heritability estimates has been heavily criticized over the years. It has been argued that these estimates are rarely valid and do not serve the purpose of tracing genetic causes. Recent contributions strike back at this criticism. I present and discuss two opposing views on these matters represented by Richard Lewontin and Neven Sesardic, and I suggest that some of the disagreement is based on differing concepts (...) of genetic causation. I use the distinction of structuring and triggering causes to help clarifying the basis for the opposing views. (shrink)

The unfairness of health inequalities depends on the more fundamental question of the relationship between justice in health and distributive justice more generally. In this article, I discuss some constraints on how health should be incorporated in a theory of justice and their implications for when health inequalities can be considered to be unfair. I argue against adopting separate distributive principles for health, and in favour of conceiving justice in health as interrelated with, and contingent on, justice in the distribution (...) of other important social goods and resources, in particular income. Accordingly, health inequalities are unfair when they are the result of an unfair distribution of resources. (shrink)

Synthetic biology research is often described in terms of programming cells through the introduction of synthetic genes. Genetic material is seemingly attributed with a high level of causal responsibility. We discuss genetic causation in synthetic biology and distinguish three gene concepts differing in their assumptions of genetic control. We argue that synthetic biology generally employs a difference-making approach to establishing genetic causes, and that this approach does not commit to a specific notion of genetic program or genetic control. Still, we (...) suggest that a strong program concept of genetic material can be used as a successful heuristic in certain areas of synthetic biology. Its application requires control of causal context, and may stand in need of a modular decomposition of the target system. We relate different modularity concepts to the discussion of genetic causation and point to possible advantages of and important limitations to seeking modularity in synthetic biology systems. (shrink)

This paper investigates the process of moral agency development as a community-supported process. Based on a multimethod qualitative inquiry, including diaries, focus groups, and documentary analysis, we analyze the experiences of middle managers in two Norwegian hospitals during the first year of the COVID-19 pandemic. We find that moral agency is developed through a community-embedded value inquiry, emerging in three partially overlapping steps. The first step is marked by moral reflex, an intuitive, value-driven, pre-reflective response to a crisis situation. In (...) the second step, the managers involved the community in value calibration, a collective-ethical sensemaking. In the third step, they took active stances to translate values into actions, with an increased awareness of values and an ability to explain and justify their actions. We label the steps, respectively: value inquiry-in-action, value inquiry-on-action and reflective enactment of value. An analysis of the process reveals two aspects critical for moral agency development: it happens through confrontation with uncertainty, and it is relational, that is, embedded in a community. While uncertainty forces an intuitive moral response, dialogical reflection in the community develops value awareness and relationships of mutual care and support. (shrink)

Automated legal reasoning and its application in smart contracts and automated decisions are increasingly attracting interest. In this context, ethical and legal concerns make it necessary for automated reasoners to justify in human-understandable terms the advice given. Logic Programming, specially Answer Set Programming, has a rich semantics and has been used to very concisely express complex knowledge. However, modelling discretionality to act and other vague concepts such as ambiguity cannot be expressed in top-down execution models based on Prolog, and in (...) bottom-up execution models based on ASP the justifications are incomplete and/or not scalable. We propose to use s(CASP), a top-down execution model for predicate ASP, to model vague concepts following a set of patterns. We have implemented a framework, called s(LAW), to model, reason, and justify the applicable legislation and validate it by translating (and benchmarking) a representative use case, the criteria for the admission of students in the “Comunidad de Madrid”. (shrink)

In the wake of corporate ethical scandals that have harmed millions of employees and investors, there has been an increase in the number of works written in the last decade, which aim to answer one apparently simple question: what causes unethical behavior, and what can we do, if anything, to prevent similar transgressions in the future? The extensive research around this question is the best proof of its real complexity as the challenge of disentangling the background of ethical behavior has (...) obvious academic and practical interest. This study aims to take a further step toward that goal. Much research has noted the impact of multiple aspects of organizational contexts on individuals’ ethical behavior. However, studies that analyze the impact of organizational learning capability (OLC) on employees’ ethical behavior are few and far between. This was the first aim of this study. The second centered on gaining a deeper understanding of the relationship between OLC and ethical behavior by analyzing the mediating role of employability and organizational commitment. We tested our hypotheses through a structural equation methodology applied to a sample of 641 workers from 166 Spanish consultancy firms and found a positive, direct relationship between OLC and employability, OLC and organizational commitment, employability and organizational commitment, and organizational commitment and ethical behavior. (shrink)

A grandfather clause is a provision whereby an old rule continues to apply to some existing situation while a new rule applies to all future cases. This paper focuses on the use of grandfather clauses in health technology appraisals (HTAs) issued by the National Institute for Health and Care Excellence (NICE) in the United Kingdom. NICE provides evidence‐based guidance on healthcare technologies and public health interventions that influence resource allocation decisions in the National Health Service (NHS) and the broader public (...) sector in England and Wales. In this context, a grandfather clause is included when NICE does not recommend treatment with a given technology. The grandfather clause provides an exemption from the general recommendation for patients who have already started treatment with the technology in question, before the publication of the NICE guidance. In this paper we first lay out the contexts in which grandfather clauses occur in NICE guidance, and then consider ethical arguments against and in support of grandfather clauses and the continuation of treatment. We argue that NICE’s current practice of automatic inclusion of a grandfather clause is ethically problematic and unfair. While the inclusion of a grandfather clause may be appropriate and justified in specific cases, we argue that inclusion of such a clause should be considered as part and parcel of the decision making process on a case by case basis, rather than adopted as the default. (shrink)

En las investigaciones sobre fisiología cardiovascular desarrolladas por William Harvey es posible distinguir entre dos teorías que responden a preguntas diferentes. La primera de ellas, que denominamos teoría del movimiento circular de la sangre, intenta dar una respuesta al problema sobre la cantidad de sangre que se mueve dentro del sistema. La segunda pretende dar cuenta de las causas de que la sangre se mueva y la denominamos teoría de las causas del movimiento de la sangre. En este trabajo, presentamos (...) una reconstrucción estructuralista de la primera de éstas, y mostramos que posee todos los componentes considerados esenciales para cualquier teoría, de acuerdo con la concepción estructuralista de la ciencia. (shrink)

How and why could some stories be construed as sacred in organizations, and what functions does the sacred have in organizational values work? Research has shown how values can be made formative of a range of organizational purposes and forms but has underscored their performative, situated, and agentic nature. We address that void by studying the sacred as a potentially salient yet under-researched realm of values work. Drawing on an ethnographic case study of a faith-based health care organization and the (...) ethical philosophy of Paul Ricoeur, we describe how the sacred is figured in two sets of tales that were lived and told with surprising intensity and consistency: the parable of the Good Samaritan and the tale of the legacy bestowed by the organization’s founder. We theorize how this figuring of the sacred in story and in action recasts values work from a centralized and unitary process to a two-way learning dialectic between the ongoing creative imitation of action and narrative. Values in the shape of stories of the sacred do not achieve their meaning as unchangeable cores or sanctioned beliefs. Rather, they come to life in a process of ongoing moral inquiry that co-evolves with moral agencies. In the latter regard, the sacred primarily becomes manifest in everyday work in the form of questioning and creative acts of care. People become moral agents when they feel and respond to the sacred in the call of the other. (shrink)

This paper proposes a five-part empirical typology of interconnections of race and class. We describe the mechanisms whereby (1) race is a form of class relation; (2) race relations and class relations reciprocally affect each other; (3) race acts as a sorting mechanism into class locations; (4) race acts as a mediating linkage to class locations; and (5) race interacts with class in determining other outcomes. Rather than insisting on one or another mechanism as the overarching framework for conceptualising the (...) interconnections between race and class, we propose a theoretical integration of all five within a functionalist model. The model reconciles the empirical effects of race variables with a class-functionalist explanation of race. Our typology of interconnections is useful for situating concrete empirical phenomena, and our theoretical integration of those interconnections offers a coherent explanatory system that captures the recursive causality of race and class. (shrink)

Reducing inequalities in health and the determinants of health is a widely acknowledged health policy goal, and methods for measuring inequalities and inequities in health are well developed. Yet, the evidence base is weak for how to achieve these goals. There is a lack of high-quality randomised controlled trials reporting impact on the distribution of health and non-health benefits and lack of methodological rigour in how to design, power, measure, analyse and interpret distributional impact in RCTs. Our overarching aim in (...) this paper is to contribute to the emerging effort to improve transparency and coherence in the theoretical and conceptual basis for RCTs on effective interventions to reduce health inequity. We endeavour to achieve this aim by pursuing two more specific objectives. First, we propose an overview of three broader health equity frameworks and clarify their implications for the measurement of health inequality in RCTs. Second, we seek to clarify the relationship between theory and translational challenges that researchers would need to attend to, in order to ensure that equity-relevant RCTs are coherently grounded in theory. (shrink)

Research on grammatical gender processing has generally assumed that grammatical gender can be treated as a uniform construct, resulting in a body of literature in which different gender classes are collapsed into single analyses. The present work reviews linguistic, psycholinguistic, and neurolinguistic research on grammatical gender from different methodologies and across different profiles of Spanish speakers. Specifically, we examine distributional asymmetries between masculine and feminine grammatical gender, the resulting biases in gender assignment, and the consequences of these assignment strategies on (...) gender expectancy and processing. We discuss the implications of the findings for the design of future gender processing studies and, more broadly, for our understanding of the potential differences in the processing reflexes of grammatical gender classes within and across languages. (shrink)

El problema de la adopción (Padró, 2015), según el cual es imposible adoptar una lógica, sugiere la idea de que la práctica de inferir es conceptualmente prioritaria a la lógica entendida como teoría. Este problema representa un desafío para la concepción antiexcepcionalista de la lógica, que entiende a los principios lógicos como meras hipótesis o como creencias sujetas a revisión. Desde nuestra perspectiva, el principal problema de esta concepción ha sido dejar abierta la pregunta sobre la naturaleza de la práctica (...) de inferir. Sin embargo, nos parece completamente posible responder esta pregunta dentro del marco teórico antiexcepcionalista. En este trabajo desarrollamos una concepción naturalista de la práctica de inferir que viene a llenar el vacío dejado por el antiexcepcionalismo tradicional; y a su vez responde al desafío lanzado por el problema de la adopción. (shrink)

Heidegger reivindicó la primacía del lenguaje poético sobre el lenguaje racional de la metafísica tradicional, pero rechazó el uso de la metáfora en él. Su discípulo Grassi atribuye a la metáfora, en cambio, una fundamental importancia filosófica, no sólo por su función en el arte, la técnica y la vida humana en general, sino también porque todo cuanto se manifiesta a través de los sentidos se carga inevitablemente de significados pasionales ajenos en sí mismos a las representaciones sensoriales, de modo (...) que todo lenguaje que expresa una realidad es en su esenciametafórico.PALABRAS CLAVE: Grassi, Heidegger, metáfora, lenguaje poético. Heidegger defended the primacy of poetic language over the racional language of traditional metaphysics, though rejecting the use of metaphor in such language. His disciple Grassi, however, attaches the greatest philosophical importance to metaphor, not only for the role it plays in art, technology, and human life in general, but also because everything that becomes manifest through the senses –where knowledge begins– inevitably becomes charged with passionate meanings in themselves alien to sensory representations; thus any language that expresses a reality is in essence metaphorical.KEYWORDS: Grassi, Heidegger, metaphor, poetic language. (shrink)